Fig. 8 | International Journal of Oral Science

Fig. 8

From: Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression

Fig. 8

LSD1 promotes STAT3 mediated OSCC progression: a, b HSC3 cells treated with SP2509 for 24 h and IL6 for 30- and 60 min shows reduced phosphorylated STAT3 (Tyr705) levels as evaluated by phospho-flow cytometry. c H&E staining of tongue tissue sections in Kdm1a−/−+4NQO shows a reduction in the pathological lesion on the tongue after 18 weeks compared to the Kdm1afl/fl + 4NQO control. d H&E staining of tongue tissue sections isolated from mice with topical application of SP2509 inhibits pathological features of OSCC (quantification and evaluation performed blindly by a board-certified oral pathologist). Statistical analyses were performed by t-test and one-way ANOVA. “ns” P > 0.05, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.000 1

Back to article page