Fig. 2

TME atlas of LSCC. a H&E maps of four samples with delineated areas of tumor cells, fibroblasts, and tumor front. Spatial distribution of epithelial/cancer cells, fibroblasts, T&NK cells, and myeloid cells (the right side of the H&E diagram). The blue numbers on the right side of the ST plot indicate the total infiltration score for each cell type throughout the image, and the red numbers indicate the mean score of every spot. Pre- and on-treatment labial photographs of patients A and B were shown. b Box plots showing the infiltration scores of different cell types in TF of pre- and on-treatment, with specific scores labeled. *P < 0.05, ***P < 0.001. c Schematic diagram of TME in LSCC under MTC. The mean values across groups were compared using a 2-tailed Student’s t-test