Fig. 8 | International Journal of Oral Science

Fig. 8

From: SMAD7 regulates the canonical Wnt signaling through TGF-β cascade crosstalk and SMAD7/β-CATENIN transcription factor complex formation during tooth regeneration

Fig. 8

SMAD7 binds to β-CATENIN to form a transcriptional complex in hDPSC. a STRING database prediction showing potential interaction between SMAD7 and β-CATENIN. b Co-IP assay showing the interaction between SMAD7 and β-CATENIN. c Immunofluorescent co-staining for SMAD7, β-CATENIN, and LEF1 in hDPSCs. Scale bar: 30 μm. d Yeast two-hybrid assay demonstrating direct interactions among SMAD7, p-SMAD2/3, and β-CATENIN. Positive colonies are indicated by red spots

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