Fig. 9 | International Journal of Oral Science

Fig. 9

From: SMAD7 regulates the canonical Wnt signaling through TGF-β cascade crosstalk and SMAD7/β-CATENIN transcription factor complex formation during tooth regeneration

Fig. 9

SMAD7 directly mediated the Wnt pathway by SMAD7/β-CATENIN transcriptional complex. a Immunofluorescent staining for SMAD7 and β-CATENIN in the nucleus of hDPSCs with or without sh-SMAD7 treatment. Scale bar: 15 μm. b Quantification of the fluorescence intensity of β-CATENIN in the nucleus. c Western blot analysis of nuclear β-CATENIN expression in control and sh-SMAD7 hDPSCs. d Immunoblotting for nuclear SMAD7 expression in control and si-CTNNB1 hDPSCs. e Schematic illustration of the direct regulatory mechanism by which SMAD7 modulates Wnt/β-catenin signaling

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