Fig. 3
From: JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities
The JAK-STAT signaling plays a pivotal role in regulating the mechanisms underlying osteogenesis, osteoclastogenesis, and the crosstalk between them. Throughout the processes of craniofacial bone development, homeostasis, and repair, there is a continuous and active interplay between osteogenic and osteoclastic activities. Key regulatory molecules, including IL-3, IL-4, IL-13 and IFN-β, are integral to this complex regulatory network. Additionally, JAK1, JAK3, STAT3, STAT5, and STAT6 serve as essential transducers of extracellular signals, while RANKL and MMP3 act as critical mediators of extracellular crosstalk within this context (Created with bioRender.com)
