Fig. 4 | International Journal of Oral Science

Fig. 4

From: Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis

Fig. 4

TNF-α, IL-1β and IL-6 are involved in Pg EV-mediated osteoclastogenesis. RAW264.7 cells were treated with EVs in the presence of neutralizing antibodies against TNF-α, IL-1β, IL-6 or IgG (2 μg/mL) for 6 days, and RANKL was used as a positive control. a–c TRAP staining was performed. d–f TRAP-positive multinuclear cells with more than 3 nuclei were counted. ns P > 0.05, ***P < 0.001. The red dashed line and arrows represent TRAP-positive osteoclasts

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