Fig. 6 | International Journal of Oral Science

Fig. 6

From: Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis

Fig. 6

Pg EVs induce osteoclastogenesis by activating Syk. Transcriptomic analysis of EVs in regulating osteoclastogenesis. a Gene set enrichment analysis (GSEA) showing the enrichment of genes involved in the osteoclast pathway activated by RANKL and EVs. b Venn diagram indicating the genes upregulated during osteoclastogenesis induced by RANKL or EVs. c Heatmap analysis was used to analyze the expression of osteoclast (OC) marker genes, RANKL signaling-related genes and Syk signaling-related genes induced by RANKL or EVs

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