Fig. 2 | International Journal of Oral Science

Fig. 2

From: Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis

Fig. 2The alternative text for this image may have been generated using AI.

Concurrent deletion of Gli2 and Gli3 in Gli1+ progenitor cells exacerbates root dysplasia. a–e Micro-CT sagittal sections, 3D reconstruction images, and HE staining of molars in control mice at P14.5 and P21.5. f–j Micro-CT sagittal sections, 3D reconstruction images, and HE staining of molars in Gli1-CreER;Gli2fl/fl mice at P14.5 and P21.5. k–o Micro-CT sections, 3D reconstruction images, and HE staining of molars in Gli1-CreER;Gli3fl/fl mice at P14.5 and P21.5. p–t Micro-CT sections, 3D reconstruction images, and HE staining of molars in Gli1-CreER;Gli2fl/fl;Gli3fl/fl mice at P14.5 and P21.5. u–w Quantitative analysis of root length in control and mutant mice at P21.5 (n = 4). White arrows denote the measurement of root length. Black arrows indicate normal alveolar bone. Red arrows indicate compromised alveolar bone. Data are presented as mean ± SD. **P < 0.01, ***P < 0.001, ****P < 0.000 1, ns, no significance. Scale bars, (b, e, g, j, l, o, q, t), 200 μm; others, 500 μm

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