Fig. 3 | International Journal of Oral Science

Fig. 3

From: Gli2 and Gli3 synergistically mediate HH-TGF-β crosstalk in mesenchymal progenitor cells to orchestrate tooth root morphogenesis

Fig. 3The alternative text for this image may have been generated using AI.

Deletion of Gli2, Gli3 or both in dental epithelium has no effect on tooth root development. a–d Micro-CT images and HE staining of molars in control mice at P21.5. e–h Micro-CT images and HE staining of molars in K14-CreER;Gli2fl/fl mice at P21.5. i-l Micro-CT images and HE staining of molars in K14-CreER;Gli3fl/fl mice at P21.5. m–p Micro-CT images and HE staining of molars in K14-CreER;Gli2fl/fl;Gli3fl/fl mice at P21.5. q–s Quantitative analysis of root length in control and mutant mice (n = 4). White arrows point to root length measurement. Black boxes represent the furcation region of the first molar. Black dotted lines indicate the area of periodontal ligament. Data are presented as mean ± SD. ns, no significance. Scale bars, (c, g, k, o), 200 μm; (d, h, l, p), 100 μm; others, 500 μm

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