Fig. 1: Conceptual overview of the approaches used in this study to derive iTTCs.
From: Developing an internal threshold of toxicological concern (iTTC)
External dose NOELs were converted using a general toxicokinetic model to generate the cumulative distribution of internal NOELs, and then lower 5th percentile internal NOEL value was divided by a 100-fold adjustment factor to calculate the iTTC.
