Fig. 2: Tiered approach and workflow for parameterizing toxicokinetics models with whole-body total (terminal) elimination rate constant (kT) and whole-body biotransformation rate constant (kB) data to calculate internal doses from the reported NOELs in the Munro TTC database [11, 39] as derived from external oral doses.
From: Developing an internal threshold of toxicological concern (iTTC)
Blood concentrations (CB or Cblood) are then calculated from whole body concentrations (CWB) as shown in Eq. (3). Absorption efficiency (AE) is used in the parameterization of the default and alternative #1 models while oral bioavailability (F) is used in the alternative model #2 calculations.
