Table 1 Summary of new iTTCs derived in this case study.

From: Developing an internal threshold of toxicological concern (iTTC)

 

Modeling approach

 
 

Default

Alternative #1

Alternative #2

Selected*

Blood iTTC (nmol/L)

0.22

0.085

0.083

0.10

Whole-body iTTC (nmol/kg)

0.74

0.29

0.23

0.50

  1. *Given the general uncertainty in the hazard and TK data, a value approximating central tendency from the three estimation methods is selected and recommended for iTTCs for organic chemicals other than those indicating genotoxicity or acetylcholinesterase inhibition.
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