Table 1 Human toxicokinetic model parameters, natural logarithm values, and prior distributions set.
Parameter | Description (unit) | Central value | Natural logarithm | Prior distribution for population geometric mean |
|---|---|---|---|---|
Cltot | Total clearance of TeA (L/Kg·hr) | 0.37 | −0.98 | LogNormal(0.37, 9.97) |
Vd | Volume of distribution of free TeA (L/kg) | 0.30 | −1.20 | LogNormal(0.30, 9.97) |
Vdmet | Volume of distribution of met. phase II TeA (L/kg) | 0.30 | −1.20 | LogNormal(0.30, 9.97) |
kufrac | Fraction of free TeA eliminated in urine | NA | NA | TruncLogNormal(0.5, 9.97, 0.01,1) |
kumet | Phase II metabolites of TeA elimination rate in urine (hr−1) | NA | NA | LogNormal(0.5, 9.97) |
kgutabs | Gut absorption rate (hr-1) | 4.96 | 1.60 | LogNormal(4.9, 9.97) |
Fgluc | Fraction of TeA urinary metabolite that is glucuronidated | NA | NA | TruncLogNormal(0.5, 9.97, 0.01,1) |
