Table 2 Post-distribution obtained for population model’s and TK parameters of tenuazonic acid (TeA).

k_gutabs

h⁻¹

4.959

12.21

23.9 [12.5–66.2]

1.14 [1.01–1.52]

Cl_tot

L/(h · kg bw)

0.3748

0.0730

1.58 [1.15–2.04]

1.60 [1.38–1.90]

Cl_met

L/(h · kg bw)

–

–

33.7 [9.67–286]

1.16 [1.01–1.49]

Vd

L/kg bw

0.3011

0.06858

4.35 [3.10–6.13]

1.67 [1.47–1.94]

Vd_met

L/kg bw

–

–

7.36 [4.54–13.1]

1.29 [1.04–1.82]

F_met

–

–

–

0.077 [0.051–0.112]

1.95 [1.68–2.35]

k_ufrac

–

–

–

0.212 [0.170–0.254]

1.49 [1.35–1.72]

t_1/2

h

0.5569

2.681

1.94 [1.35–2.74]

2.36 [2.05–2.73]

k_el

h⁻¹

1.245

0.3730

0.357 [0.253–0.512]

2.36 [2.05–2.73]

AUC^a

ng-h/L

398.74

1.449

952 [774–1310]

1.60 [1.38–1.90]

MAT

h

0.2016

0.08189

0.042 [0.015–0.080]

1.14 [1.01–1.52]

T_max

h

0.3722

1.394

0.21^b

1.13^b

C_max

ng/ml

4.981

1.061

0.32^b

1.74^b