Fig. 4: Altered inflammatory profile in East Palestine residents. | Journal of Exposure Science & Environmental Epidemiology

Fig. 4: Altered inflammatory profile in East Palestine residents.

From: Characterizing immune perturbations in peripheral blood following the East Palestine, Ohio train derailment

Fig. 4: Altered inflammatory profile in East Palestine residents.The alternative text for this image may have been generated using AI.

A Bubble plot comparing plasma immune mediators between EP and control. Size represents analyte concentration, and color represents the calculated p-value between the two groups. (# = p < 0.1, * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001). B Sparse partial least squares discriminant analysis (sPLS-DA) on plasma immune mediator concentrations. The X- and Y-axis refer to the first and second components, respectively. The percentage of variance for each component is in parentheses on the associated axis. C The contribution of the immune mediators to the first component. D Frequencies of IL-6/TNFα and IL-1β / MIP-1β secretions by classical monocytes and non-classical monocytes following bacterial stimulation. E Frequencies of IL-6 / TNFα and IL-1β / MIP-1β secretions by pDCs and mDCs following bacterial stimulation.

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