Table 2 Recommendations related to pregnancy in hypertension guidelines.
Aspects/recommendations | WHO 2021 [9] | ISH 2020 [10] | ESC/ESH 2018 [2] | ACC/AHA 2017 [3]a | Latin American 2016 [11] | NICE 2019 [https://www.nice.org.uk/guidance/ng133]b | Australian 2016 [29]c | Japanese 2019 [34] | Chinese 2018 [33] | |
|---|---|---|---|---|---|---|---|---|---|---|
Definition of hypertension in pregnancy (mmHg) | ≥140/90 | ≥140/90 | ≥140/90 | ≥140/90 | ≥140/90 | ≥140/90 | ≥140/90 | ≥140/90 | NR | ≥140/90 |
Classification of hypertensive disorders in pregnancy | √ | √ | √ | √ | NR | √ | √ | √ | √ | √ |
Aspirin to prevent preeclampsia in high-risk pregnancy | NR | Yes, 75–162 mg 12th week | Yes, 100–150 mg 12th week | Yes, 60–80 mg late 1st trimester | Yes, 100 mg, before 6th week | Yes, 75–150 mg 12th week | Yes, low dose | NR | Yes, low dose, 12th week | NR |
Treatment of severe hypertension | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ |
Treatment of non-severe hypertension | If comorbidities | √ | √ | No | No | √ | Individualize | No | √ | √ |
On-treatment BP target of severe hypertension (mmHg) | NR | NR | NR | 140–150/90–99 | NR | 130–150/80–100 | NR | <160/110 | NR | <150/100 Not <80 |
BP threshold to initiate drug treatment in non-severe hypertension (mmHg) | ≥160/105 Diastolic >90 (if comorbidities) | >150/95 | >150/95 or >140/90 if comorbidities | <160/110 only if comorbidities | ≥160/110 | ≥140/90 | ≥140/90 | NR | ≥150/100 | >150/95 |
On-treatment BP target of mild hypertension (mmHg) | NR | NR | <140/90 | NR | NR | <135/85 Not <110/70 | NR | NR | <150/100 Not <130/80 | <150/100 Not <80 |
Preferred agent(s) to treat severe hypertension | NR | iv labetalol iv esmolol iv urapidiliv nicardipine | iv labetalol po nifedipine | iv hydralazine po nifedipine | NR | iv labetalol po nifedipine iv hydralazine | iv labetalol po nifedipine iv hydralazine | iv nicardipine iv nitroglycerin iv hydralazine | NR | iv labetalol |
Preferred agents to treat non-severe hypertension | po labetalol po nifedipine po verapamil po methyldopa po hydralazine | po labetalol po nifedipine po nicardipine po methyldopa | po labetalol po calcium channel blockers | po labetalol | po labetalol po methyldopa po nifedipine po amlodipine | po labetalol po methyldopa po nifedipine po enalaprilb | po labetalol po methyldopa po nifedipine po oxprenolol | po labetalol po methyldopa po nifedipined po hydralazinee | po labetalol po methyldopa po nifedipine | po labetalol po methyldopa po nifedipine |
