Table 6 Research Recommendations.

From: Investigation and management of resistant hypertension: British and Irish Hypertension Society position statement

Research Questions

1. What is the most effective drug combination for people with RH?

2. What are the pathophysiological mechanisms underpinning aldosterone production in people with RH?

3. Are MRAs (such as spironolactone) superior to other agents (such as amiloride) in preventing major adverse cardiovascular events in people with RH?

4. What is the role of aldosterone synthase inhibitors and nsMRAs in the management of people with RH?

5. What is the role of SGLT2 inhibitors and GLP-1 agonists in the management of people with RH?

  1. RH resistant hypertension, MRA mineralocorticoid receptor antagonists, nsMRA non-steroidal mineralocorticoid receptor antagonists, SGLT2 Sodium-glucose co-transporter 2, GLP-1 glucagon-like peptide 1.
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