Table 3 Additive interaction between hypertension and depression on all-cause mortality and CVD.

From: Independent and joint associations of hypertension and depression with cardiovascular diseases and all-cause mortality: a population-based cohort study

Outcomes

Additive interaction

Multiplicative interaction (95% CI)

RERI (95% CI)

AP (95% CI)

SI (95% CI)

All-cause mortality

0.087 (−0.346–0.519)

0.056 (−0.223–0.336)

1.198 (0.461–3.111)

1.053 (0.745–1.487)

CVD

−0.309 (−0.691–0.072)

−0.140 (−0.322–0.424)

0.795 (0.607–1.052)

0.722 (0.588–0.886)

Stroke

−0.908 (−1.648–0.166)

−0.321 (−0.608–0.034)

0.667 (0.485–0.918)

0.882 (0.705–1.102)

Cardiac events

−0.019 (−0.380–0.343)

−0.009 (−0.190–0.171)

0.981 (0.687–1.401)

0.513 (0.376–0.700)

  1. Multivariable-adjusted for age, gender, education, marital status, residence, BMI, drinking, smoking, and chronic comorbidities.
  2. AP attributable proportion. It indicates the proportion of the risk that is due to interaction among individuals with both exposures. AP = RERI/OR hypertension and depression. RERI relative excess risk for interaction. It indicates the excess risk due to the interaction relative to the risk without exposure. RERI = OR hypertension and depression - OR hypertension - OR depression+1. SI synergy index. It represents the excess risk from both exposures when there is interaction relative to the risk from exposure without interaction. SI = [OR hypertension and depression -1]/[(OR hypertension - 1)+(OR depression - 1)].
Back to article page