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Survey of ECMO practices for infants with hypoxic ischemic encephalopathy

Journal of Perinatology volume 38, pages 1197–1204 (2018)Cite this article

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Abstract

Objective

Historically, some physicians are reluctant to offer extracorporeal membrane oxygenation (ECMO) to infants with neonatal encephalopathy. This study describes how ECMO practices have changed since the development of therapeutic hypothermia (TH) for neonatal encephalopathy.

Study design

A 22-question electronic survey was sent to neonatal medical directors and ECMO directors in the USA and Canada. Participants were queried on TH and ECMO practices and if they would offer ECMO given certain clinical factors; confidential responses were compared with a similar survey conducted in 2008.

Result

A total of 356 physicians were invited to participate, and the response rate was 25%. Seventy-two percent had initiated or referred for ECMO during cooling therapy. Compared with the 2008 survey, participants were more likely to offer ECMO for moderate and severe encephalopathy. Ninety-four percent offer hypothermia for neonatal encephalopathy, but only 24% have written ECMO criteria for such patients. Neonatologists were more likely than non-neonatologists to offer ECMO for mild and moderate encephalopathy.

Conclusion

ECMO use with neonatal encephalopathy has increased since TH has become standard care. Wide variability in practice remains with important differences between neonatologists and non-neonatologists.

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Acknowledgements

We thank Dr. Steven Peterec, Yale School of Medicine Division of Neonatal-Perinatal Medicine, for sharing 2008 survey results and Dr. Amanda Preston, Le Bonheur Children’s Hospital Children’s Foundation Research Institute, for her review of this manuscript.

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Authors and Affiliations

  1. Division of Neonatology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

    Mark F. Weems & Kirtikumar Upadhyay

  2. Le Bonheur Children’s Hospital and University of Tennessee Health Science Center, Memphis, Tennessee, USA

    Mark F. Weems, Kirtikumar Upadhyay & Hitesh S. Sandhu

  3. Division of Pediatric Critical Care, University of Tennessee Health Science Center, Memphis, Tennessee, USA

    Hitesh S. Sandhu

Authors
  1. Mark F. Weems
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  2. Kirtikumar Upadhyay
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  3. Hitesh S. Sandhu
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Correspondence to Mark F. Weems.

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The authors declare that they have no conflict of interest.

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Weems, M.F., Upadhyay, K. & Sandhu, H.S. Survey of ECMO practices for infants with hypoxic ischemic encephalopathy. J Perinatol 38, 1197–1204 (2018). https://doi.org/10.1038/s41372-018-0167-y

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