Table 2 Univariate and multivariate logistic regression analysis of selected variables associated with BPD

From: Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants

Variables

Univariate

Multivariate

 

RR (95% C.I.)

P value

RR (95% C.I.)

P value

Ibuprofen exposure

2.694 (1.458, 4.975)

0.001

2.296 (1.166, 4.522)

0.016

Gestational age

0.480 (0.364, 0.633)

 < 0.001

0.498 (0.374, 0.662)

 < 0.001

1 min Apgar Score

0.791 (0.684, 0.915)

0.002

−

0.118

5 min Apgar Score

0.747 (0.565, 0.986)

0.009

−

0.971

Birth weight

0.996 (0.994, 0.998)

 < 0.001

−

0.236

Intubation

2.385 (1.286, 4.423)

0.005

−

0.686

Surfactant

4.500 (1.309, 15.464)

0.010

−

0.356

HsPDA

2.929 (1.574, 5.452)

0.001

−

0.857

  1. BPD was diagnosed when supplemental oxygen required at 36 weeks PMA. HsPDA (hemodynamically significant PDA) was defined as the presence of a ductus with a diameter > 1.5 mm, LA/AO (left atrial inner diameter/aortic root) ≥ 1.4, combined left to right shunt
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