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Factors associated with development of early and late pulmonary hypertension in preterm infants with bronchopulmonary dysplasia

Journal of Perinatology volume 40, pages 138–148 (2020)Cite this article

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Abstract

Objective

To investigate factors associated with development of early and late pulmonary hypertension (E/LPH) in preterm infants with bronchopulmonary dysplasia (BPD).

Study design

A retrospective case-control observational study of preterm infants with BPD admitted to a level IV referral neonatal intensive care unit over 5 years. We compared pre- and postnatal characteristics between infants with or without BPD-associated EPH and LPH.

Results

Fifty-nine out of 220 infants (26.8%) had LPH, while 85 out of 193 neonates (44%) had EPH. On multiple logistic regression, novel factors associated with development of BPD–LPH included presence of maternal diabetes, EPH, tracheostomy, tracheitis, intraventricular hemorrhage (IVH, grade ≥3) and systemic steroid use. For EPH, these were maternal diabetes, IVH grade ≥3, high frequency ventilator use, and absence of maternal antibiotics use.

Conclusion

We identified novel factors and confirmed previously established factors with development of LPH and EPH, which can help develop a screening strategy in BPD patients.

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Acknowledgements

The authors are grateful to Alison Carey, MD from St. Christopher’s Hospital for Children, Philadelphia, PA for her critical review of the paper.

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Authors and Affiliations

  1. Department of Neonatal-Perinatal Medicine, St. Christopher’s Hospital for Children, Philadelphia, PA, USA

    Sudip Sheth, Vineet Bhandari & Anja Mowes

  2. Drexel University College of Medicine, Philadelphia, PA, USA

    Sudip Sheth, Lisa Goto, Vineet Bhandari, Boban Abraham & Anja Mowes

  3. Department of Pediatric Cardiology, St. Christopher’s Hospital for Children, Philadelphia, PA, USA

    Boban Abraham

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  1. Sudip Sheth
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Correspondence to Anja Mowes.

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Sheth, S., Goto, L., Bhandari, V. et al. Factors associated with development of early and late pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. J Perinatol 40, 138–148 (2020). https://doi.org/10.1038/s41372-019-0549-9

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