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Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC)

Journal of Perinatology volume 41, pages 1025–1032 (2021)Cite this article

Subjects

Abstract

Objective

Identify antenatal and neonatal factors associated with primary outcome of EUGR.

Methods

1063 preterm infants from a subset of the BBC were included in this prospective cohort study. Regression analysis was carried out to evaluate associations of EUGR with antenatal factors and neonatal factors.

Results

6.1% of the infants had in-utero growth restriction (IUGR) at birth and 21.7% of infants had EUGR. The adjusted odds ratio for EUGR status were significant for birth weight (OR 0.99, p = 0.00, CI 0.99–0.99), for GA at birth (OR 4.58, p = 0.00, CI 3.25–6.44), for PDA (OR 2.9, p = 0.02, CI 1.17–7.1), for NEC (OR 5.14, p = 0.012, CI 1.44–18.3) and for day of life of reaching full feeds (OR 1.04, p = 0.001, CI 1.01–1.06).

Conclusion

This study highlights important factors associated with EUGR. Additional studies are needed to gain further insight.

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Funding

The Boston Birth Cohort (the parent study, PI, XW) was supported in part by the March of Dimes PERI grants (20-FY02-56, #21-FY07-605), the Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Human Services (HHS) under grant number R40MC27443, Autism Field-initiated Innovative Research Studies Program; and grant number UJ2MC31074, Autism Single Investigator Innovation Program; and the National Institutes of Health (NIH) grants (R21ES011666, 2R01HD041702, R21HD066471, U01AI090727, R21AI079872, R01HD086013, R01HD098232, R21AI154233, and R01ES031272). This information or content and conclusions are those of the author and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS or the US Government.

Author information

Authors and Affiliations

  1. Division of Neonatology Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Kartikeya Makker

  2. Center on the Early Life Origins of Disease, Department of Population Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Yuelong Ji, Xiumei Hong & Xiaobin Wang

  3. Division of General Pediatrics, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Xiaobin Wang

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  1. Kartikeya Makker
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Correspondence to Kartikeya Makker.

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Makker, K., Ji, Y., Hong, X. et al. Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC). J Perinatol 41, 1025–1032 (2021). https://doi.org/10.1038/s41372-021-00948-4

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