Table 2 Odds of high seizure burden and abnormal neurological examination at discharge based on radiologic diagnosis and injury location in 236 children with acute provoked neonatal seizures.
From: Neonatal brain MRI and short-term outcomes after acute provoked seizures
MRI Findings | High Seizure Burden | Abnormal Neuro Examination at Discharge | ||
|---|---|---|---|---|
Minimally Adjusted* | Fully Adjusted/Multivariate* | Minimally Adjusted* | Fully Adjusted/Multivariate* | |
Imaging Diagnoses | ||||
Normal MRI (N = 22) | 0.13 [0.04–0.45], p < 0.001 | 0.49 [0.16–1.5], p < 0.21 | ||
HIE (N = 67) | 2.4 [1.3–4.4], p < 0.006 | 2.7 [1.4–5.4], p < 0.003 | 2.2 [1.1–3.7], p < 0.02 | |
Ischemic Stroke (N = 84) | 0.90 [0.52–1.6], p < 0.71 | 0.7 [0.4–1.3], p < 0.30 | ||
Intracranial Hemorrhage (N = 62) | 1.8 [0.96–3.4], p < 0.07 | 3.2 [1.6–6.5], p < 0.001 | 0.9 [0.45–1.7], p < 0.67 | |
Infection (N = 6) | 2.5 [0.76–8.1], p < 0.13 | 4.2 [1.4–12.0], p < 0.008 | 3.9 [1.3–11.6], p < 0.01 | |
Other diagnosis (N = 51) | 0.44 [0.22–0.85], p < 0.02 | 0.75 [0.4–1.5], p < 0.43 | ||
Injury Location | ||||
Cortical Injury (N = 118) | 2.9 [1.7–5.1], p < 0.001 | 3.5 [1.9-6.4], p < 0.001 | 1.5 [0.86–2.7], p < 0.16 | |
Deep Gray Injury (N = 89) | 1.7 [1.0–3.0], p < 0.05 | 2.8 [1.6–5.0], p < 0.001 | 2.7 [1.6–5.0], p < 0.001 | |
Other Injury Location (N = 61) | 0.64 [0.35–1.2], p < 0.15 | 0.51 [0.26–1.03], p < 0.06 | ||
