Table 1 Maternal and neonatal characteristics.
From: What drives outcomes in infants of mothers with congenital heart disease? A mediation analysis
Maternal characteristics | Â | No maternal CHD | Maternal CHD | p-value |
|---|---|---|---|---|
N | Â | 15 698 | 3 533 | Â |
Maternal age | <18 years | 264 (1.7%) | 56 (1.6%) | 0.90 |
|  | 18–34 years | 12 222 (77.9%) | 2 759 (78.1%) |  |
| Â | >34 years | 3 212 (20.5%) | 718 (20.3%) | Â |
Parity | Nulliparous | 5 911 (37.7%) | 1 635 (46.3%) | <0.001 |
| Â | Multiparous | 9 787 (62.3%) | 1 898 (53.7%) | Â |
Delivery Mode | Vaginal delivery | 10 294 (65.6%) | 2 079 (58.8%) | <0.001 |
| Â | C-section | 5 404 (34.4%) | 1 454 (41.2%) | Â |
MPSa | No | 14 434 (91.9%) | 3 047 (86.2%) | <0.001 |
| Â | Yes | 1 264 (8.1%) | 486 (13.8%) | Â |
Preeclampsia | No | 15 015 (95.6%) | 3 247 (91.9%) | <0.001 |
| Â | Yes | 683 (4.4%) | 286 (8.1%) | Â |
Gestational hypertension | No | 15 244 (97.1%) | 3 389 (95.9%) | <0.001 |
| Â | Yes | 454 (2.9%) | 144 (4.1%) | Â |
Placental abruption | No | 15 555 (99.1%) | 3 471 (98.2%) | <0.001 |
| Â | Yes | 143 (0.9%) | 62 (1.8%) | Â |
Metabolic syndromeb | No | 15 339 (97.7%) | 3 316 (93.9%) | <0.001 |
| Â | Yes | 359 (2.3%) | 217 (6.1%) | Â |
Type 2 diabetes | No | 15 616 (99.5%) | 3 490 (98.8%) | <0.001 |
| Â | Yes | 82 (0.5%) | 43 (1.2%) | Â |
Preexisting hypertension | No | 15 472 (98.6%) | 3 392 (96.0%) | <0.001 |
| Â | Yes | 226 (1.4%) | 141 (4.0%) | Â |
Dyslipidemia | No | 15 633 (99.6%) | 3 485 (98.6%) | <0.001 |
| Â | Yes | 65 (0.4%) | 48 (1.4%) | Â |
Maternal Obesity | No | 12 352 (78.7%) | 2 774 (78.5%) | 0.83 |
| Â | Yes | 3 346 (21.3%) | 759 (21.5%) | Â |
Congestive heart failure | No | 15 682 (99.9%) | 3 409 (96.5%) | <0.001 |
| Â | Yes | 16 (0.1%) | 124 (3.5%) | Â |
Infection during pregnancy | No | 13 617 (86.7%) | 2 784 (78.8%) | <0.001 |
| Â | Yes | 2 081 (13.3%) | 749 (21.2%) | Â |
Chorioamnionitis | No | 15 227 (97.0%) | 3 369 (95.4%) | <0.001 |
| Â | Yes | 471 (3.0%) | 164 (4.6%) | Â |
Other infection | No | 13 997 (89.2%) | 2 896 (82.0%) | <0.001 |
| Â | Yes | 1 701 (10.8%) | 637 (18.0%) | Â |
Neonatal characteristics | ||||
N | Â | 15 720 | 3 930 | Â |
Sex | female | 7 651 (48.7%) | 1 934 (49.2%) | 0.54 |
| Â | male | 8 069 (51.3%) | 1 996 (50.8%) | Â |
Prematurity | No | 14 406 (91.6%) | 3 382 (86.1%) | <0.001 |
| Â | Yes | 1 314 (8.4%) | 548 (13.9%) | Â |
Multiple Gestation | No | 15 242 (97.0%) | 3 786 (96.3%) | 0.046 |
| Â | Yes | 478 (3.0%) | 144 (3.7%) | Â |
SGA | No | 14 299 (91.0%) | 3 425 (87.2%) | <0.001 |
| Â | Yes | 1 421 (9.0%) | 505 (12.8%) | Â |
CCHD | No | 15 656 (99.6%) | 3 858 (98.2%) | <0.001 |
| Â | Yes | 64 (0.4%) | 72 (1.8%) | Â |
Other major malformations or chromosomal anomalies | No | 15 401 (98.0%) | 3 794 (96.5%) | <0.001 |
| Â | Yes | 319 (2.0%) | 136 (3.5%) | Â |
