Table 2 Univariable and multivariable analysis for pregnancy outcomes.

From: What drives outcomes in infants of mothers with congenital heart disease? A mediation analysis

 

Prematurity

Offspring with CCHD

 

Crude OR (95% CI)

Adjusted ORa (95% CI)

Crude OR (95% CI)

Adjusted ORa (95% CI)

Maternal ACHD

1.69 (1.51–1.89)

1.34 (1.19–1.51)

4.79 (3.40–6.76)

4.74 (3.34–6.74)

MPS

4.92 (4.37–5.54)

4.59 (4.07–5.18)

1.48 (0.89–2.47)

1.21 (0.72–2.04)

Metabolic Syndrome

2.12 (1.70–2.64)

1.76 (1.39–2.22)

1.82 (0.85–3.92)

1.28 (0.59–2.78)

Pregnancy infection

1.60 (1.42–1.81)

1.40 (1.23–1.59)

0.97 (0.60–1.59)

1.19 (0.37–3.84)

Maternal CHF

6.31 (4.47–8.89)

3.60 (2.47–5.23)

3.22 (1.01–10.24)

0.78 (0.48–1.28)

  1. CHD congenital heart disease, MPS maternal placental syndrome, CHF congestive heart failure, OR odds ratio, CI confidence interval.
  2. aadjusted for all other mediators listed in the table.
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