Fig. 2: Observed/predicted plasma L-citrulline concentration (μmol/L) time profiles.
Solid black lines represent predicted plasma L-citrulline concentrations. Dotted black lines represent 50 μmol/L and 80 μmol/L concentrations and reflect the target trough plasma concentrations. Black dots are the observed L-citrulline concentrations (μmol/L) collected at study time points (i.e. at baseline and trough prior to the 12th dose of L-citrulline). Note that 2 subjects had the same trough L-citrulline concentration of 53 μmol/L at the second study time point so that dot reflects the data for 2 subjects.
