Table 2 Performance of clinical decision rules based on longitudinal sMNAS-9 metrics in the independent test set including 190 infants with 31,710 MNAS scores.
From: Abstinence scoring algorithms for treatment of neonatal opioid withdrawal syndrome (NOWS)
Full MFNAS criteria | Matching sMNAS-9 criteria | Sensitivity (95% CI) | Specificity (95% CI) |
|---|---|---|---|
Average 24 h score <8 | Average 24 h sMNAS-9 scores < 4.6 | 92.5% (92.2–92.8) | 92.1% (91.2–93.4) |
Single MNAS score ≥12 (*) | Single sMNAS-9 score ≥7 | 97.2% (96.4–98.0) | 94.8% (94.7–95.0) |
Average 24 h NAS score ≤8 | Average 24 h sMNAS-9 scores ≤ 4.6 | 91.9% (91.6–92.2) | 94.4% (93.5–95.3) |
Sum of 3 consecutive MFNAS ≥ 24 | Sum of 3 consecutive sMNAS-9 ≥ 14 | 92.9% (92.1–93.8) | 89.7% (89.3–90.0) |
Sum of 3 consecutive MFNAS ≥ 28 | Sum of 3 consecutive sMNAS-9 ≥ 16 | 95.3% (94.1–96.4) | 93.0% (92.7–93.3) |
Sum of 3 consecutive MFNAS < 18 | Sum of 3 consecutive sMNAS-9 ≤ 10 | 88.6% (88.2–89.1) | 85.4% (84.7–86.0) |
