Table 2 Preadmission patent ductus arteriosus therapy among outborn patients.
Total cohort | (1) 2011–2013 | (2) 2014–2016 | (3) 2017–2019 | (4) 2020–2022 | p | |
|---|---|---|---|---|---|---|
Patients, n | 17,438 | 3799 | 4229 | 4635 | 4775 | |
Pharmacotherapy for PDA, n (%) | 7166 (41.1) | 1661 (43.7) | 1649 (39) | 1847 (39.8) | 2009 (42.1) | <0.001 |
Indomethacin only, n (%) | 4293 (24.6) | 1511 (39.8) | 1252 (29.6) | 958 (20.7) | 572 (12) | <0.001 |
Ibuprofen only, n (%) | 1196 (6.9) | 120 (3.2) | 326 (7.7) | 364 (7.9) | 386 (8.1) | <0.001 |
Acetaminophen only, n (%) | 905 (5.2) | 0 (0) | 2 (0) | 261 (5.6) | 642 (13.4) | <0.001 |
Multiple medications for PDA, n (%) | 772 (4.4) | 30 (0.8) | 69 (1.6) | 264 (5.7) | 409 (8.6) | <0.001 |
Definitive PDA closure, n (%) | 782 (4.5) | 249 (6.6) | 220 (5.2) | 182 (3.9) | 131 (2.7) | <0.001 |
