Table 4 Individual echocardiographic parameters: no PDA versus low PDA shunt burden group.

From: Association of low shunt burden from PDA and adverse outcomes in premature infants

 

No burden (n = 69)

Low burden (n = 43)

p value

Iowa PDA score components

 Mitral valve E wave velocity, cm/s

37.8 ± 8.8

43.4 ± 9.3

<0.001

 IVRT, msec

49.9 ± 11.1

51.2 ± 11.2

0.448

 Pulmonary vein D wave, cm/s

28.3 ± 8.5

29.1 ± 8.3

0.539

 Left atrium: aorta

1.28 ± 0.2

1.33 ± 0.2

0.124

 LVO:RVO

1.07 ± 0.5

1.07 ± 0.3

0.994

 PDA size: weight, mm/kg

1.65 ± 1.1

1.06 ± 0.7

<0.001

Additional TNE information and markers

 PMA at the time of TNE

26.97 ± 2.1

27.33 ± 2.3

0.251

 Weight at the time of TNE

0.85 ± 0.3

0.94 ± 0.3

0.066

 Pulmonary vein S wave, cm/s

32.2 ± 8.3

34.9 ± 8.9

0.027

 Mitral valve A wave velocity, cm/s

52 ± 9.6

59.2 ± 10.4

<0.001

 Mitral valve E:A ratio

0.73 ± 0.15

0.74 ± 0.13

0.799

 TAPSE, mm

5.2 ± 1.3

5.6 ± 1.3

0.048

 RV S’, cm/s

4.9 ± 1

5.3 ± 1.1

0.025

 RV FAC, %

0.46 ± 0.1

0.47 ± 0.1

0.492

 EF by Simpson’s biplane, %

66.4 ± 7.2

67.7 ± 6.8

0.224

 LVO, ml/min/kg

166.2 ± 42

192.6 ± 50

<0.001

 RVO, ml/min/kg

171 ± 62

189.6 ± 58

0.040

 PDA size, mm

1.36 ± 0.6

1.02 ± 0.5

0.003

  1. Data are presented as mean ± SD.
  2. PDA patent ductus arteriosus, IVRT isovolumic relaxation time, LVO left ventricular output, RVO right ventricular output, TNE targeted neonatal echocardiogram, PMA post menstrual age, TAPSE tricuspid annular plane systolic excursion, RV right ventricular, FAC fractional area change, EF ejection fraction.
  3. Bolded p-values are those that are statistically significant.