Table 2 Clinical outcomes by AKI status.

From: Prolonged patent ductus arteriosus exposure and risk for late acute kidney injury in extremely preterm infants

 

No AKI

(N = 177)

Any AKI

(N = 39)

P valuea

Stage 2/3

AKI

(N = 27)

P valueb

Bronchopulmonary dysplasia

     

Grade 1

124 (70)

14 (36)

<0.001

8 (30)

<0.001

Grade 2

40 (23)

8 (21)

 

6 (22)

 

Grade 3

13 (7)

17 (44)

 

13 (48)

 

Patent ductus arteriosus

53 (30)

11 (28)

0.83

8 (30)

1.00

Moderate to large PDA

41 (23)

10 (26)

0.74

7 (26)

0.76

Pharmacologic treatment of PDA

48 (27)

13 (33)

0.44

10 (37)

0.28

Grade 3-4 intracranial hemorrhage

21 (12)

2 (5)

0.22

0 (0)

0.06

Early onset sepsis

2 (1)

2 (5)

0.09

1 (4)

0.45

Late onset sepsis

28 (16)

11 (28)

0.07

9 (33)

0.03

Severe retinopathy of prematurity

36 (20)

7 (18)

0.74

5 (19)

0.85

Necrotizing enterocolitis stage ≥ 2

17 (10)

8 (21)

0.05

8 (30)

0.002

Pulmonary hypertension

60 (34)

22 (56)

0.009

15 (56)

0.04

Death

11 (6)

14 (36)

<0.001

13 (48)

<0.001

  1. aNo AKI vs Any AKI.
  2. bNo AKI and stage 1 AKI v Stage 2 and 3 AKI.