Table 3 Interaction between PDA (definition A) or PDA Ligation (definition B) and the study primary outcomes.
Outcome | Subgroups | Late surfactant N = 252 | Control N = 259 | Adjusted odds ratio* (95% CI) | P value for interaction |
|---|---|---|---|---|---|
Survival without BPD at 36 weeks’ PMA | PDA | 25/89 (28.1%) | 22/94 (23.4%) | 1.09 (0.66–1.79) | 0.41 |
No PDA | 54/162 (33.3%) | 60/164 (36.6%) | 0.97 (0.75–1.26) | ||
Survival without BPD at 36 weeks’ PMA | PDA ligation | 15/55 (27.3%) | 12/51 (23.5%) | 0.86 (0.45–1.66) | 0.84 |
No PDA ligation | 64/196 (32.7%) | 70/207 (33.8%) | 1.05 (0.81–1.36) | ||
Survival without BPD at 40 weeks’ PMA | PDA | 51/89 (57.3%) | 43/93 (46.2%) | 1.09 (0.84–1.41) | 0.33 |
No PDA | 97/162 (59.9%) | 97/163 (59.5%) | 1.01 (0.87–1.17) | ||
Survival without BPD at 40 weeks’ PMA | PDA ligation | 32/55 (58.2%) | 23/51 (45.1%) | 0.96 (0.64–1.44) | 0.42 |
No PDA ligation | 116/196 (59.2%) | 117/205 (57.1%) | 1.03 (0.89–1.19) |
