Fig. 5 | Laboratory Investigation

Fig. 5

From: Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma

Fig. 5

GPX4 knockdown promotes ROS-induced cell death in LCL-K cells. a Knockdown efficiency of GPX4 was detected at the mRNA level by qRT-PCR. GPX4 mRNA expression level was significantly decreased in GPX4-knockdown LCL-K cells (P = 0.0306). b Knockdown efficiency of GPX4 was detected at the protein level by western blot. c Densitometry analysis shows that GPX4 band intensity was significantly decreased in GPX4-knockdown LCL-K cells (P = 0.0013). d Cell death rate was significantly increased in GPX4-knockdown LCL-K cells compared with that of control LCL-K cells after treatment with TBHP (P = 0.0111). e Mean cell death rate was not significantly different between LG and LC cells after treatment with etoposide (P = 0.1574). shGPX4; GPX4-knockdown LCL-K cells.;*P < 0.05; n.s., non-significant

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