Table 3 Univariate and multivariate analyses of clinicopathological factors influencing overall survival

Variable	Category	Number of patients	P-value by log-rank test	HR^a	95% Cl^b	P-value by Cox proportional hazards
Age	≥65y	53	0.6654
Age	<65y	40	0.6654
Gender	Male	59	0.6266
Gender	Female	34	0.6266
Ann Arbor stage	I, II	52	0.0030	0.8535	0.2071–3.5181	0.8265
Ann Arbor stage	III, IV	41	0.0030	0.8535	0.2071–3.5181	0.8265
LDH^c	Normal	35	0.0166	1.3538	0.4691–3.9068	0.5754
LDH^c	Elevated	58	0.0166	1.3538	0.4691–3.9068	0.5754
Performance status	0–1	61	<0.0001	4.5595	1.6516–12.5875	0.0034
Performance status	2–4	32	<0.0001	4.5595	1.6516–12.5875	0.0034
B symptoms	Yes	31	<0.0001	2.4129	0.9075–6.4152	0.0775
B symptoms	No	62	<0.0001	2.4129	0.9075–6.4152	0.0775
Extranodal site	0	33	0.0690
Extranodal site	≥1	60	0.0690
Bone marrow involvement	Yes	15	0.0016	1.5652	0.5611–4.3662	0.3921
Bone marrow involvement	No	78	0.0016	1.5652	0.5611–4.3662	0.3921
Hans algorithm	GCB^d	59	0.8615
Hans algorithm	Non-GCB	34	0.8615
GPX4	Positive	33	0.0002	4.5345	1.8538–11.0914	0.0009
GPX4	Negative	60	0.0002	4.5345	1.8538–11.0914	0.0009

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