Fig. 1 | Laboratory Investigation

Fig. 1

From: Lack of hepatic stimulator substance expression promotes hepatocellular carcinoma metastasis partly through ERK-activated epithelial–mesenchymal transition

Fig. 1

HSS expression in HCC tissue samples. a Samples from 44 cases of patients with HCC were collected and relative HSS mRNA expression was tested by qRT-PCR. qRT-PCR measurement of HSS transcript was normalized to β-actin transcript in 44 cases. Data are expressed as mean ± SD, ***P < 0.001. HSS mRNA expression is significantly decreased in HCC tissues with vascular invasion as compared with those of non-vascular invasion, which were corrected with adjacent non-tumor tissues. b HCC patients with HSS high expression (solid line) had better survival rate comparing with patients with low expression (P = 0.022). c HSS expression was displayed in eight cases of HCC patients by immunofluorescence. HSS high expression was seen in the samples without vascular invasion. In contrast, HSS low expression was shown in the HCC tissue with vascular invasion. Isotype control was used as negative control. d Western blot confirmed that 23 kDa HSS expression was down-regulated in the cases with vascular invasion.

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