Fig. 4 | Laboratory Investigation

Fig. 4

From: Microvascular fractal dimension predicts prognosis and response to chemotherapy in glioblastoma: an automatic image analysis study

Fig. 4

mvFD inversely correlates with microvasculature-normalized tumor proliferation. a–c Scatter plots and linear regression analyses showing the correlation between mvFD and Ki67 index. d IHC images labeled with anti-CD34 or anti-Ki67 antibody in GBM cases with different mvFD values. Scale bars: 50 μm. e Scatter plot and linear regression analysis showing the correlation between mvFD and Ki67/mvFD. a–c, e The red straight line in each panel is the best fit line of linear regression. The red dotted lines in each panel are the 95% confidence band of the best fit line. r, correlation coefficient. f, g Kaplan–Meier curves showing the differences of PFS (f) and OS (g) of GBM patients based on Ki67/mvFD value. f, g Log-rank test was used to obtain the P-value with the average value of Ki67/mvFD in the GBM group used as the cut-off point to discriminate high (>21.6) and low (≤21.6) subgroups. The statistical difference is significant when P < 0.05

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