Fig. 1 | Laboratory Investigation

Fig. 1

From: Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency

Fig. 1

Effect of western type died on body weight and bone composition in APOE deficient mice and wild type controls. In Fig.1, mean ± SD, N = 5. a, b APOE deficient mice fed WTD mice display significantly reduced body weight in comparison to C57BL/6 WTD mice at week 6, 12, 18, and 24 of the experiment (a). Note the remarkable differenced in the physical appearance between mice that belong to the two experimental groups (b). c Hematoxylin and eosin stain on sections obtained from mouse femora showed that the APOE deficient mice consumed WTD for 24 weeks had virtually no BM adipocytes, in sharp contrast to their WT legitimates (bone marrow adipocytes are pointed by yellow arrows) (original magnification 4×). d Collagen cross-linking study for control WTD and knockout WTD mice, determined by Raman spectroscopy, revealed that the APOE deficient mice fed WTD had a substantial increase (41%) in the collagen cross-links, compared to the C57BL/6 WTD mice. Statistical significance was considered at p value less than 0.05

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