Table 1 Chronic angiotensin II infusion increases systolic blood pressure in both Ssh1+/+ and Ssh1−/− mice

From: The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo

 

N

Systolic blood pressure

Diastolic blood pressure

Mean arterial pressure

Ssh+/+

    

 D0

20

100.3 ± 1.81

74.1 ± 2.63

80.4 ± 2.74

 D7

13

147.8 ± 4.48 *

124.8 ± 5.48 *

133.2 ± 5.2 *

 D14

7

157.3 ± 3.3 **

126.9 ± 5.89 **

136.5 ± 5.88 **

Ssh1−/−

 D0

18

106 ± 3.16

79.8 ± 2.32

88.5 ± 2.6

 D7

14

160.6 ± 4.24 #

128.8 ± 5.81 #

139.7 ± 5.07 #

 D14

7

160.6 ± 6.186 ##

133.4 ± 8.41 ##

143.4 ± 8.44 ##

  1. Mice were implanted with osmotic minipumps containing Ang II (750 ng/kg/day) or saline. Blood pressure was measured by tail-cuff plethysmography over the course of 14 days (Ssh1+/+ D0 vs. D7, *p < 0.001, n = 13–20 mice per group; Ssh1+/+ D0 vs. D14, **p < 0.001, n = 7–20 mice per group; Ssh1−/− D0 vs. D7, #p < 0.001, n = 14–18 mice per group; Ssh1−/− D0 vs. D14, ##p < 0.001, n = 7–18 mice per group)
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