Fig. 4 | Laboratory Investigation

Fig. 4

From: p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation

Fig. 4

Histology/IHC of p17 in the CA1 hippocampus and local cortical regions. Showed that EGFR1 was observed in local cortical microvessels (i ×40 and ii ×200; Nickel DAB and p17-DAB brown; arrows). (iii) Shows cytoplasmic localisation of EGFR1 in cortical neurones adjacent to the p17 injection point (Nickel-DAB; ×400). And iv, shows EGFR1 expression in local hippocampal neurones (arrows; vector blue ×400). (v) Shows non-injected control hippocampal region with negative EGFR1 staining whilst vi, shows control IHC with the primary antibody replaced by PBS. In all 10 sections from five p17-injected murine brains were analysed together with 3 control mice

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