Fig. 2
From: Protective effect and mechanism of IL-10 on renal ischemia–reperfusion injury
IL-10 knockout worsened the ischemic AKI. Renal pedicles of IL-10 KO mice and WT littermates were clamped for 30 min. Blood and kidney tissues samples were collected at 5 (n = 6), 24 (n = 6), 48 (n = 6), and 120 h (n = 5) after renal IRI. ‘0 h’ indicates samples from mice that did not undergo the operation. a, b BUN and sCr were measured as indications of kidney function in mice exposed to IRI. c Representative morphology (by PAS staining) of kidney cortex from WT and IL-10 KO mice at 48 h and sham-operated mice. d ATN (acute tubular necrosis) score after IRI: Tissue damage was scored in the cortex. The data are mean ± SEM. *p < 0.05, WT vs. IL-10 KO mice at 24 and 48 h. Original magnification, ×400
