Fig. 2
From: Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry
Quantitative detection of 2-HG by GC-MS in IDH1-mutated gliomas. a The concrete 2-HG concentration. b High accumulation of 2-HG appears to be dominant in young patients (age < 35 years), middle-aged patients (35 years ≤ age ≤ 60 years), and c GBM samples. d Dose-dependent activity of 2-HG on epigenetic regulation by IHC. Representative IHC data in IDH1 mutant glioma tissues (two left panels; the 2-HGhigh and 2-HGlow groups) and WT tumors (right panel) are shown. Scale bars represent 100μm. Furthermore, quantification of these epigenetic modification intensity is shown. Mean ± SEM, 2-tailed t-test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001
