Table 1 Multivariate Cox-regression analyses of miRNA SNPs for PFS

From: miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs

miRNAs

SNPs

Genotypes

Patients

Hubei cohort

Patients

Shandong cohort

No. (%)

HR (95% CI)

P

No. (%)

HR (95% CI)

P

miR-499

rs3746444

TT

114 (70.4)

Reference

 

106 (67.5)

Reference

 
  

TC

44 (27.2)

1.19 (0.82–1.72)

0.368

48 (30.6)

0.92 (0.59–1.45)

0.730

  

CC

4 (2.4)

N.C.

N.C.

3 (1.9)

N.C.

N.C.

miR-608

rs4919510

GG

51 (31.5)

Reference

 

44 (28.0)

Reference

 
  

GC

74 (45.7)

0.58 (0.40–0.85)

0.006

80 (51.0)

1.18 (0.73–1.93)

0.499

  

CC

37 (22.8)

0.63 (0.49–0.81)

3.0 × 10−4

33 (21.0)

0.63 (0.45–0.87)

0.005

miR-3152

rs13299349

GG

126 (77.8)

Reference

 

121 (77.1)

Reference

 
  

GA

34 (21.0)

1.26 (0.83–1.90)

0.277

33 (21.0)

1.01 (0.62–1.66)

0.959

  

AA

2 (1.2)

N.C.

N.C.

3 (1.9)

N.C.

N.C.

miR-4513

rs2168518

GG

112 (69.1)

Reference

 

118 (75.2)

Reference

 
  

GA

46 (28.4)

0.46 (0.31–0.67)

8.0 × 10−5

37 (23.6)

0.40 (0.24–0.68)

0.001

  

AA

4 (2.5)

N.C.

N.C.

2 (1.2)

N.C.

N.C.

miR-4520a

rs8078913

TT

73 (45.1)

Reference

 

75 (47.8)

Reference

 
  

TC

69 (42.6)

0.65 (0.45–0.94)

0.022

65 (41.4)

0.86 (0.57–1.30)

0.477

  

CC

20 (12.3)

1.10 (0.84–1.46)

0.491

17 (10.8)

0.91 (0.60–1.37)

0.642

  1. HRs and 95% CIs for the association between clinical variables and recurrence or death risk were adjusted for age of onset, sex, smoking status, and stage, where it was appropriate
  2. miRNA microRNA, SNP single nucleotide polymorphism, PFS progression-free survival time, HR hazard ratio, CI confidence interval, N.C. not calculated
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