Fig. 1 | Laboratory Investigation

Fig. 1

From: Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

Fig. 1

Suppression of naphthalene/gefitinib-induced body weight loss and mortality by H2-rich water. Changes in body weight during the study period (a) and at day 4 (b) after injection of naphthalene (N) or corn oil (O) (vehicle). Mice were given control water (CW) or H2-rich water (HW) freely, with or without oral administration of gefitinib (G). Data are expressed as the mean ± SEM. Mice were divided into five groups as follows: O with CW (n = 8), N with CW (n = 8), N with HW (n = 8), N + G with CW (n = 11), and N + G with HW (n = 9). **P < 0.01 vs. the control group (O with CW) in a. **P < 0.01 in b. Kaplan-Meier curve representing the survival of mice treated with naphthalene and gefitinib (c). All mice in each group without ones in N + G with CW group survived and only survival curves of N + G with CW and N + G with HW groups are shown. P, log-rank test

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