Fig. 1

Trisomy rescue. a Karyotypic analysis in T21-iPSC #1. All of the cells (20 out of 20 cells) had typical trisomy karyotypes (47, XX, +21). b Karyotypic analysis in T21-iPSC #5. All of the cells (20 out of 20 cells) had typical trisomy karyotypes (47, XX, +21). c Karyotypic analysis in T21-iPSC #6. All of the cells (20 out of 20 cells) had typical trisomy karyotypes (47, XX, +21). d Karyotypic analysis in T21-iPSC #9. All of the cells (20 out of 20 cells) had typical trisomy karyotypes (47, XX, +21). e Karyotypic analysis in T21-iPSC #12. All of the cells (20 out of 20 cells) had typical trisomy karyotypes (47, XX, +21). This panel is duplicated from the reference 34. f Karyotypic analysis in D21-iPSC#1. D21-iPSC#1 had normal karyotypes (46, XX). g Karyotypic analysis in D21-iPSC#2. D21-iPSC#2 had normal karyotypes (46, XX). h FISH analysis in T21-iPSC#12 that was trisomic for chromosome 21. i FISH analysis in D21-iPSC#1 that was disomic for chromosome 21. j FISH analysis in D21-iPSC#2 that was disomic for chromosome 21. k STR analysis of T21-iPSC#12, D21-iPSC#1 and D21-iPSC#2