Fig. 1 | Laboratory Investigation

Fig. 1

From: Potential MMP2-mediated availability of HLA binding, mutant ECM peptides reflects better melanoma survival rates and greater T-cell infiltrates

Fig. 1

Kaplan–Meier (KM) curves representing barcodes with mutant AA adjacent to MMP2 sites, for SKCM, BRCA, and KIRC. a KM overall survival (OS) curve for Skin Cutaneous Melanoma (SKCM) barcodes representing ECM structural mutant AA adjacent to MMP2-sensitive sites (n = 197, arrow), compared with the OS for all remaining barcodes (n = 268). Mean OS for the barcodes representing ECM structural mutant AA adjacent to MMP2-sensitive sites, 107.29 months; mean OS for all remaining barcodes, 63.30 months. Log rank comparison p-value, p = 0.028. b KM OS curve for Breast Invasive Carcinoma (BRCA) barcodes representing ECM structural mutant AA adjacent to MMP2-sensitive sites (n = 64, arrow), compared with the OS for all remaining barcodes (n = 1032). Mean OS for the barcodes representing ECM structural mutant AA adjacent to MMP2-sensitive sites, undefined months; mean OS for all remaining barcodes, 129.47 months. Log rank comparison p-value, p = 0.478. c KM OS curve for Kidney Renal Clear Cell Carcinoma (KIRC) barcodes representing ECM structural mutant AA adjacent to MMP2-sensitive sites (n = 36, arrow), compared with the OS for all remaining barcodes (n = 500). Mean OS for the barcodes representing ECM structural mutant AA adjacent to MMP2-sensitive sites, undefined months; mean OS for all remaining barcodes, 90.41 months. Log-rank comparison p-value, p = 0.681

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