Fig. 1 | Laboratory Investigation

Fig. 1

From: Reliable identification of prostate cancer using mass spectrometry metabolomic imaging in needle core biopsies

Fig. 1

Proliferation rates in prostate cancer cases profiled by DESI-MSI. Proliferation rate of cells increases from benign to cancer (p = 1.6e-07, Mann–Whitney U test) and from low/intermediate grade cancer to high grade cancer (trend). Graph shows mean proliferation rate (positive cells/total cells) per case calculated by Ki67 immunohistochemistry and automated digital scoring shows increased proliferation rate in cancer compared to benign cells. Ki67 labeling analysis and DESI-MSI were performed on the same cases. For this and subsequent figures, the colored box depicts 50% of the intensity value data. Heavy line = median, whiskers show the lesser of the furthest value or 1.5 times the inter-quartile range in each direction, and the open circles are outlier data

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