Fig. 4 | Laboratory Investigation

Fig. 4

From: Multimodal analysis of formalin-fixed and paraffin-embedded tissue by MALDI imaging and fluorescence in situ hybridization for combined genetic and metabolic analysis

Fig. 4

A tissue microarray (TMA) containing 69 human gastroesophageal adenocarcinoma samples was measured by MALDI FT-ICR metabolome imaging. Molecules, e.g., Hex-P (hexose phosphate), GDP (guanosine diphosphate), AMP (adenosine monophosphate), are visualized exemplarily on six tissue cores in heatmap coloring according to the biopsies, which are displayed in Fig. 2. The samples are either HER2 amplified (upper panel) or non-amplified (lower panel). Measured m/z values of the metabolites can be obtained from the last row. The panels a–f refer to the same tissue cores as shown in Fig. 5

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