Fig. 3

a Subclonal structure of relapsed and metastatic tumors. Mutations were clustered into four groups based on the cellular prevalence of the mutations. The size of the oval represents the average cellular prevalence of the cluster. The numbers of mutations in each cluster are labeled below. b Cellular prevalence distribution of mutations in the relapsed and metastatic tumors. c Dynamics of mutations between relapsed and metastatic tumors. The relationship between mutations in the relapsed and metastatic tumors is indicated by the lines linking them