Table 1 Summary of the effect of siRNA-mediated silencing of store-operated Ca2+ entry components on EGTA-AM, cytochalasin D (cyto D), and thapsigargin-induced vimentin expression in MDA-MB-468 cells

From: Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli

 

siORAI1

siSTIM1

siTRPC1

EGTA-AM

↓

↓

↓

Cyto D

↔

↓

↓

Thapsigargin

↓

↓

↑

  1. Thapsigargin and cytochalasin D both use a STIM1-dependent pathway for vimentin expression in MDA-MB-468 breast cancer cells but differentially engage ORAI1 and TRPC1. EGTA-AM-induced vimentin expression is STIM1, ORAI1, and TRPC1 sensitive. ↑, increased; ↓, decreased; ↔ no change, vimentin expression relative to non-targeting control
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