Fig. 10 | Laboratory Investigation

Fig. 10

From: Retinoid-related orphan nuclear receptor alpha (RORα)-deficient mice display morphological testicular defects

Fig. 10

Digital colored TEM of the interstitial tissue of both control and mutant mice. a WT mice showing interstitial cell cytoplasm (IC) contained smooth endoplasmic reticulum (sER), mitochondria (M), lysosomes (L), and lipid droplets (lds). The telocytes (TCs) consisted of cell bodies and telopodes (Tps), which contained rough endoplasmic reticulum (rER), mitochondria (M), and many secretory vesicles (arrowheads). b Interstitial cell cytoplasm (IC) of WT mice demonstrating peripherally arranged clumps of heterochromatin. c Telocyte (TC) of WT mice revealing many secretory vesicles (arrowheads). d, e Mutant mice showing interstitial cells (IC) contained many lysosomes (L), lipid droplets (lds), many vacuoles (V), sER, and degenerated mitochondria (M). Note: Fibroblasts (F), and Macrophages (MA) with many electron-dense lysosomes. Telocytes (TCs) were distributed around the blood capillaries (BC). f Dendritic reticular cell (DC) was demonstrated around the lymphatic vessels (LV) in the mutant mice. Telocytes (TCs) were distributed around the lymphatic vessels (LV). Note: telopodes (Tps) of adjacent TCs were connected together

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