Fig. 2

Appearance of vertebral trabecular bone at 8 and 16 weeks. Static histomorphometry was done by micro-computed tomography (µCT). MicroCT was performed using a Skyscan 1172 instrument (Bruker) at 6 µm resolution with 0.5 mm aluminum filter. Cross-sectional images were obtained using Dataviewer software and three-dimensional images using the CTvox software (Bruker). In both cases, at 8 and 16 weeks, the central vertebral bone density is less than in the KO although the difference is clearer, and significant for the entire vertebral bodies, at 16 weeks